O'Keefe

Searching for my O'Keefe ancesters.  My 3rd Great Grandfater was born in 1797 in Ireland.  His wife was Margaret was born 1800 in Ireland.  They immigrated from Ireland to Phiadelphia area.  Their children were Michael born 1830, Margaret born 1842, and James 1848.  James is my 2nd great grandfather.  I would appreciate any help with this.